Upgrading medicine in Phantom Blade Zero boosts the percentage of HP, damage negation, and Sha-Chi that these healing consumables replenish, which is quite powerful, as you might expect.
You can upgrade your medicine once you reach the Green Serpent House in west Pangzhen, the game’s fourth region after the Village of Lu. You’ll arrive at this location during Pangzhen’s second chapter, which has you exploring the west side of the town—specifically after defeating Xie Qiudong, the Divine Healer—and proceeding down the street, where you’ll spot a large house with green banners and the Green Serpent House bell.
The Apprentice Healer here will upgrade your medicine using Apprentice Healer’s Memories and Skilled Healer’s Memories, some of which you’ll likely have already collected during your explorations. You’ll also receive the Green Serpent Brew medicine, which removes status effects, when you visit for the first time.
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